Origins of Light Sensitivity

The Evolutionary Origins of Light Sensitivity

The evolutionary origins of complex innovations like eyes are contentious and interesting because they involve multiple interacting components. Using phototransduction as a model, we are showing how investigating individual components of complex systems can elucidate their origins. Phototransduction underlies animal vision, utilizing numerous proteins to translate light information into nervous impulses. We are determining the components involved in phototransduction in the eyeless cnidarian Hydra magnipapillata and its relative with complex lens-eyes, the box jellyfish Tripedalia cystophora. We've found that Cnidaria are the only non-bilaterian animals with opsin-based phototransduction. Therefore, by determining how vision and phototransduction work in Cnidaria, we can make inferences about the very origins of phototransduction – and by extension eyes and vision – in all animals.

Our work has established that some key genes used in phototransduction of bilaterian animals, like flies, mollusks and vertebrates, are also used in cnidarian phototransduction. We test these hypotheses by integrating a variety of methods, including genomics, phylogenetics, confocal microscopy, behavioral assays, pharmacology, transgenics and RNA-interference.

Selected Publications

Affiliated Researchers

Our lab addresses the question of how complex traits originate during evolution. We primarily study invertebrate visual systems and eyes, addressing questions like, when did a particular phenotype evolve? When did the components of that phenotype evolve? Where did those components come from? What evolutionary processes and mechanisms were involved?

Aide is interested in the molecular basis of evolution in cnidarian vision.

Rebecca Varney is interested in the interplay of stress and the evolution of novel traits and works mainly in aquatic invertebrate systems.